GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4785204 | 1 | rs58069930 | chr16:50067031 | HEATR3 | chr16:50099881-50139373:+ | -0.4 | -6.11 | 2.09E-9 | Esophageal cancer (squamous cell) |
| THCA | cis | rs8105815 | 1 | rs58073287 | chr19:41666680 | BCKDHA | chr19:41882438-41930909:+ | -0.18 | -3.41 | 0.000694 | Prion diseases |
| THCA | cis | rs477692 | 1 | rs580745 | chr10:131414401 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.42 | 7.4E-27 | Response to temozolomide |
| THCA | cis | rs867186 | 1 | rs58088385 | chr20:33748229 | PROCR | chr20:33758727-33765164:+ | -0.32 | -5.35 | 1.36E-7 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs58088385 | chr20:33748229 | TRPC4AP | chr20:33590215-33680618:- | 0.32 | 4.15 | 3.92E-5 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs12435908 | 1 | rs58115860 | chr14:66057626 | LOC645431 | chr14:65877313-65879335:- | -0.6 | -7.74 | 6.15E-14 | Ischemic stroke |
| THCA | cis | rs7216064 | 1 | rs58122682 | chr17:65876915 | C17orf58 | chr17:65987218-65989765:- | 0.2 | 3.97 | 8.17E-5 | Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma |
| THCA | cis | rs709400 | 1 | rs58133129 | chr14:104104759 | KLC1 | chr14:104029299-104167887:+ | -0.21 | -4.22 | 2.87E-5 | Body mass index |
| THCA | cis | rs17122021 | 1 | rs58162302 | chr11:118146199 | AMICA1 | chr11:118064442-118095809:- | 0.08 | 4.01 | 7.05E-5 | Pain |
| THCA | cis | rs17122021 | 1 | rs58162302 | chr11:118146199 | MPZL2 | chr11:118124135-118135009:- | 0.23 | 7.86 | 2.62E-14 | Pain |
| THCA | cis | rs17122021 | 1 | rs58162302 | chr11:118146199 | TREH | chr11:118528942-118550381:- | -0.17 | -3.39 | 0.000746 | Pain |
| THCA | cis | rs2129782 | 1 | rs58164144 | chr8:89437770 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs515910 | 1 | rs581686 | chr10:105983356 | C10orf79 | chr10:105889647-105992120:- | 0.24 | 7.76 | 5.25E-14 | Attention deficit hyperactivity disorder |
| THCA | cis | rs6988636 | 1 | rs58177772 | chr8:124188067 | FAM83A | chr8:124191287-124222317:+ | -0.34 | -4.39 | 1.41E-5 | Urinary uromodulin levels |
| THCA | cis | rs6988636 | 1 | rs58189203 | chr8:124184739 | FAM83A | chr8:124191287-124222317:+ | -0.34 | -4.25 | 2.56E-5 | Urinary uromodulin levels |